Vaccination with the drug is contraindicated for the following categories of patients:
- patients with hypersensitivity to vaccine components;
- patients with hypersensitivity to eggs and chicken protein, another chicken component;
- patients with fever or insufficient nutrition;
- patients with chronic kidney or liver failure, acute cardiovascular and respiratory diseases, other infectious diseases;
- persons who had convulsions within 1 year before vaccination;
- patients with Guillain-Barré syndrome within 6 weeks after previous vaccination against influenza or patients with neurological disorders;
- persons with immunodeficiency;
- patients until full recovery or persons in the incubation period of the disease;
- persons who had a fever the day before or allergy symptoms, for example, a generalized rash during a previous vaccination.

Local reactions such as redness, swelling and pain and general reactions such as fever, chills, headache, tiredness and vomiting are possible. Such reactions, as a rule, pass within 2-3 days.
Rarely, acute disseminated encephalomyelitis may develop.
Fever, headache, convulsions, dyskinesia, and confusion usually occur within 2 weeks of vaccine administration. If these symptoms are suspected, appropriate treatment is carried out, the diagnosis must be confirmed by MRI or other diagnostic methods. Very rarely, an allergic reaction or anaphylactic shock may occur.
Temporary disorders of the central and peripheral nervous system are rarely possible. Cases of paralysis, neuralgia, cerebral hemorrhage, or inflammation of the nervous system (eg, Guillain-Barré syndrome) have been reported.