Hypersensitivity to the active substances or to any component of the vaccine, including severe allergic reactions to yeast. In individuals who develop symptoms suggestive of hypersensitivity after administration of a dose of Gardasil, administration of the next dose of vaccine is contraindicated. As with other vaccines, the use of Gardasil should be delayed if the patient has an acute illness accompanied by fever. The presence of a mild infection, such as a minor upper respiratory tract infection or a low-grade fever, is not a contraindication to vaccination.

Pain, swelling, redness at the injection site.
An increase in body temperature.
Pain in the muscles, joints.
Chills.
Fatigue, drowsiness.
Serious complications are extremely rare (anaphylactic reactions, bronchospasm, urticaria, convulsions).